Research Area F - Publications 2007
07-Nov-2007
Degeneration of dopaminergic neurons in the substantia nigra is characteristic for Parkinson’s disease (PD), the second most common neurodegenerative disorder. Mitochondrial dysfunction is believed to contribute to the etiology of PD. Although most cases are sporadic, recent evidence points to anumberof genes involved in familial variants of PD.Amongthem, a ...
FTLD-U linked missense mutations in the progranulin gene reduce progranulin production and secretion
05-Nov-2007
http://www.jbc.org, online article
Loss of function mutations in progranulin cause tau-negative frontotemporal lobar degeneration with ubiquitin positive inclusions. A major protein component of these inclusions is TDP-43, which becomes hyperphosphorylated, ubiquitinated and cleaved to generate C-terminal fragments, which apparently translocate from nuclei to the cytoplasm. Most progranulin ...
25-Oct-2007
J. Biol. Chem., 2007, doi/10.1074/jbc.M706661200, published on 25.10.2007
http://www.jbc.org, online article
Presenilin, the catalytic component of the gamma-secretase complex, type IV prepilin peptidases and signal peptide peptidase (SPP) are the founding members of the family of intramembrane cleaving GxGD aspartyl proteases. SPP-like (SPPL) proteases, such as SPPL2a, b, and c and SPPL3 also belong to the GxGD family. In contrast to gamma-secretase, where numerous ...
24-Oct-2007
Alzheimer's disease (AD) amyloid beta-peptide (Aß) is generated via proteolytic processing of the ß-amyloid precursor protein (APP) by ß- and gamma-secretase. gamma-Secretase can be blocked by selective inhibitors but can also be modulated by a subset of non-steroidal anti-inflammatory drugs (NSAIDs) including sulindac sulfide. These drugs selectively reduce the ...
18-Sep-2007
Mol. Neurobiol., 2007, 35, 266-77 published on 18.09.2007
Molecular Neurobiology, online article
Channels directly gated by cyclic nucleotides (CNG channels) are important cellular switches that mediate influx of Na+ and Ca2+ in response to increases in the intracellular concentration of cAMP and cGMP. In photoreceptors and olfactory receptor neurons, these channels serve as final targets for cGMP and cAMP signaling pathways that are initiated by the ...
04-Sep-2007
The mammalian main olfactory epithelium (MOE) recognizes and transduces olfactory cues through a G protein-coupled, cAMPdependent signaling cascade. Additional chemosensory transduction mechanisms have been suggested but remain controversial. We show that a subset of MOE neurons expressing the orphan receptor guanylyl cyclase GC-D and the cyclic nucleotide-gated ...
10-Aug-2007
The Journal of Biological Chemistry, online article
gamma-Secretase is an intramembrane aspartyl protease complex that cleaves type I integral membrane proteins, including the amyloid beta-protein precursor (APP) and the Notch receptor, and is composed of presenilin, Pen-2, nicastrin and Aph-1. Although all four of these membrane proteins are essential for assembly and activity, the stoichiometry of the complex is ...
06-Jul-2007
EMBO reports, 2007, 1-6 (pdf) published on 06.07.2007
Gamma-Secretase is involved in the production of amyloid beta-peptide, which is the principle component of amyloid plaques in the brains of patients with Alzheimer disease. Gamma-Secretase is a complex composed of presenilin (PS), nicastrin, anterior pharynx-defective phenotype 1 (Aph1) and PS enhancer 2 (Pen2). We previously proposed a mechanism of complex ...
29-Jan-2007
J. Biol. Chem., 2007, 282 Nr. 14, 10632-8 (pdf) published on 29.01.2007
www.jbc.org, online article
The assembly of the gamma-secretase complex, an Alzheimer disease-related protease required for ß-amyloid generation, is tightly regulated and predominantly limited by the stoichiometrical availability of its components. We have identified a novel endoplasmic reticulum-located protein complex that is regulatedin a similar fashion. It contains the recently ...
Campus Movie 2020
Campus Movie 2012
